Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
A.M. Schoelermann, K.A. Jung, B. Buck, E. Grönniger, S. Conzelmann
, Journal of the European Academy of Dermatology and Venereology, Volume30, IssueS1 Special Issue: Sensitive Skin – A Global Challenge with Upcoming Solutions
Both products alleviated capsaicin-induced burning during the first 15 min after application. A faster and more pronounced soothing effect in vivo was demonstrated for the 4-t-butylcyclohexanol containing cosmetic product in comparison to the acetyl dipeptide-1 cetyl ester containing cosmetic formulation.
Usage of Synthetic Peptides in Cosmetics for Sensitive Skin
Diana I. S. P. Resende 1,2,†,Marta Salvador Ferreira 3,4,†,José Manuel Sousa-Lobo 3,4,Emília Sousa 1,2,andIsabel Filipa Almeida 3,4
, Pharmaceuticals 2021, 14(8), 702;
Peptides were found in 17% of the products analyzed, namely: acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-8, acetyl tetrapeptide-15, palmitoyl tripeptide-5, acetyl hexapeptide-49, palmitoyl tetrapeptide-7 and palmitoyl oligopeptide. Noteworthy, acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-8, and acetyl tetrapeptide-15 are neurotransmitter-inhibiting peptides acting as agonists from cutaneous opioid system, such as µ receptor, which interacts with TRVP1 receptors through intracellular signaling.
